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PQQ (Pyrroloquinoline quinone) is a compound found naturally in many foods and in the soil. PQQ was recently discovered and researchers are still finding new evidence of it being beneficial in many aspects of our lives. The dosage is very small but it packs a big punch. It has been shown to increase energy levels and extend life spans. It has shown to have antioxidant properties, reduce inflammation, improve sleep, boost brain power, and even lower cholesterol levels.

Many scientific research studies support the use of PQQ and indicate it may have some of the following benefits:

1. Improve memory (1,4)
2. Improve attention (
3. Improve judgement (
4. Improve cognitive function (
5. Reduce inflammation (
6. Prevent reduction of brain function (
7. Improve sleep (
8. Improve reaction to stress (
9. Improve quality of life (

Scientific Studies Cited

1. Improvements in memory, attention, judgement, and cognitive function

“Results: Study demonstrates that supplementation of PQQ disodium salt is useful in improving memory, attention, judgment, and cognitive function, in middle-aged to elderly population, who feel they have become more forgetful because of aging”

Yoshiaki Shiojima, Megumi Takahashi, Ryohei Takahashi, Hiroyoshi Moriyama, Debasis Bagchi, Manashi Bagchi, Masanori Akanuma (2021) Effect of Dietary Pyrroloquinoline Quinone Disodium Salt on Cognitive Function in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study, Journal of the American College of Nutrition, 2021 Aug 20;1-14, DOI: 10.1080/07315724.2021.196277


2. Improvements in cognitive function and inflammation

“Results: However, dietary PQQ exposure (Study 1) resulted in apparent changes in antioxidant potential based on malonaldehyde-related TBAR assessments. In Study 2, PQQ supplementation resulted in significant decreases in the levels of plasma C-reactive protein, IL-6 and urinary methylated amines such as trimethylamine N-oxide, and changes in urinary metabolites consistent with enhanced mitochondria-related functions.”

Calliandra B Harris, Winyoo Chowanadisai, Darya O Mishchuk, Mike A Satre, Carolyn M Slupsky, Robert B Rucker (2013) Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects, The Journal of nutritional biochemistry, 2013 Dec;24(12):2076-84, DOI: 10.1016/j.jnutbio.2013.07.008


3. Improvements in cognitive function

“Results: These results suggest that PQQ causes increased activity in the right PFC associated with increases in rCBF and oxygen metabolism, resulting in enhanced cognitive function.”

Masahiko Nakano, Yuta Murayama, Lizhen Hu, Kazuto Ikemoto, Tatsuo Uetake, Kaoru Sakatani (2016) Effects of Antioxidant Supplements (BioPQQ™) on Cerebral Blood Flow and Oxygen Metabolism in the Prefrontal Cortex, Advances in experimental medicine and biology, 2016;923:215-222, DOI: 10.1007/978-3-319-38810-6_29


4. Improvements in attention, memory, and preventing reduction of brain function

“Results: The results suggest that PQQ can prevent reduction of brain function in aged persons, especially in attention and working memory.”

Yuji Itoh, Kyoko Hine, Hiroshi Miura, Tatsuo Uetake, Masahiko Nakano, Naohiro Takemura, Kaoru Sakatani (2016) Effect of the Antioxidant Supplement Pyrroloquinoline Quinone Disodium Salt (BioPQQ™) on Cognitive Functions, Advances in Experimental Medicine and Biology, 2016;876:319-325, DOI: 10.1007/978-1-4939-3023-4_40

5. Improvements in sleep, stress, and quality of life

“Results: For example, the results of the Profile of Mood States-Short Form revealed that all six measures of vigor, fatigue, tension-anxiety, depression, anger-hostility and confusion were significantly improved following PQQ administration compared with scores for those measures before administration of PQQ. Measures for quality of life, appetite, sleep, obsession and pain, also improved significantly.”

Masahiko Nakano, Tetsuro Yamamoto, Hisayoshi Okamura, Akira Tsuda, and Yasuyuki Kowatari (2012) Effects of Oral Supplementation with Pyrroloquinoline Quinone on Stress, Fatigue, and Sleep, Functional Foods in Health and Disease, 2012, 2(8):307-324